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Contrave is often a combination from the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of several active ingredient, which may make them far better and safer. Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular could be the fact that as of right now there aren't long term prescription diet pills that have been authorized by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and heart rate, and really should not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, as well as by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients to the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. Approving a drug with this particular many potentially lethal unwanted side effects is inconsistent with the mission statement of the FDA. The power in the drug manufacturing lobby is blatantly evident within the approval of many drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety within the US.